Influence of Mechanical Stimuli on Schwann Cell Biology

Influence of Mechanical Stimuli on Schwann Cell Biology

Blog Article

Schwann cells are the glial cells of the peripheral nervous system (PNS).They insulate axons by forming a specialized extension of plasma membrane called the myelin sheath.The formation of myelin is essential for A Lazy Bailout Approach for Dual-Criticality Systems on Uniprocessor Platforms the rapid saltatory propagation of action potentials and to maintain the integrity of axons.

Although both axonal and extracellular matrix (ECM) signals are necessary for myelination to occur, the cellular and molecular mechanisms regulating myelination continue to be elucidated.Schwann cells in peripheral nerves are physiologically exposed to mechanical stresses (i.e.

, tensile, compressive and shear strains), occurring during development, adulthood and injuries.In addition, there is a growing body of evidences that Schwann cells are sensitive to the stiffness of their environment.In this review, we detail the mechanical constraints of Schwann cells and peripheral nerves.

We explore the regulation of Schwann cell signaling pathways in response to mechanical stimulation.Finally, we provide a comprehensive overview of the experimental studies addressing the mechanobiology of Schwann cells.Understanding which mechanical properties can interfere with the cellular and molecular biology of Schwann cell during development, myelination and following injuries opens new insights in Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts the regulation of PNS development and treatment approaches in peripheral neuropathies.